@article {679133,
	title = {Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke},
	journal = {Mayo Clin Proc},
	volume = {95},
	number = {5},
	year = {2020},
	month = {2020 05},
	pages = {955-965},
	abstract = {OBJECTIVE: To determine whether brain volume is associated with functional outcome after acute ischemic stroke (AIS).

PATIENTS AND METHODS: This study was conducted between July 1, 2014, and March 16, 2019. We analyzed cross-sectional data of the multisite, international hospital-based MRI-Genetics Interface Exploration study with clinical brain magnetic resonance imaging obtained on admission for index stroke and functional outcome assessment. Poststroke outcome was determined using the modified Rankin Scale score (0-6; 0~= asymptomatic; 6~= death) recorded between 60 and 190 days after stroke. Demographic characteristics and other clinical variables including acute stroke severity (measured as National Institutes of Health Stroke Scale score), vascular risk factors, and etiologic stroke subtypes (Causative Classification of Stroke system) were recorded during index admission.

RESULTS: Utilizing the data from 912 patients with AIS (mean {\textpm} SD age, 65.3{\textpm}14.5 years; male, 532 [58.3\%]; history of smoking, 519 [56.9\%]; hypertension, 595 [65.2\%]) in a generalized linear model, brain volume (per 155.1 cm3) was associated with age (β~-0.3 [per 14.4 years]), male sex (β 1.0), and prior stroke (β~-0.2). In the multivariable outcome model, brain volume was an independent predictor of modified Rankin Scale score (β~-0.233), with reduced odds of worse long-term functional outcomes (odds ratio, 0.8; 95\% CI, 0.7-0.9) in those with larger brain volumes.

CONCLUSION: Larger brain volume quantified on clinical magnetic resonance imaging of patients with AIS at the time of stroke purports a protective mechanism. The role of brain volume as a prognostic, protective biomarker has the potential to forge new areas of research and advance current knowledge of the mechanisms of poststroke recovery.},
	keywords = {Aged, Brain, Brain Ischemia, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Recovery of Function, Stroke},
	issn = {1942-5546},
	doi = {10.1016/j.mayocp.2020.01.027},
	author = {Schirmer, Markus D and Donahue, Kathleen L and Nardin, Marco J and Dalca, Adrian V and Giese, Anne-Katrin and Etherton, Mark R and Mocking, Steven J T and McIntosh, Elissa C and Cole, John W and Holmegaard, Lukas and Jood, Katarina and Jimenez-Conde, Jordi and Kittner, Steven J and Lemmens, Robin and Meschia, James F and Rosand, Jonathan and Roquer, Jaume and Rundek, Tatjana and Sacco, Ralph L and Schmidt, Reinhold and Sharma, Pankaj and Slowik, Agnieszka and Stanne, Tara M and Vagal, Achala and Wasselius, Johan and Woo, Daniel and Bevan, Stephen and Heitsch, Laura and Phuah, Chia-Ling and Strbian, Daniel and Tatlisumak, Turgut and Levi, Christopher R and Attia, John and McArdle, Patrick F and Worrall, Bradford B and Wu, Ona and Jern, Christina and Lindgren, Arne and Maguire, Jane and Thijs, Vincent and Rost, Natalia S}
}